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Cystic Fibrosis
Fibrin And Blood Clotting
Gene Therapy and Viruses
DNA
Chromatin
Cell Division
Bacterial Motility
Molecular Motors
Other
Biomedical Research
The majority of the Resource is directed toward biomedical research, focusing on these specific areas:
Cystic
Fibrosis
This collaboration is applying the new capabilities
afforded by nanometer-resolution 3D force microscope to two unsolved biophysical
problems in mucociliary clearance: the behavior and fate of periciliary
liquid during mucus transport, and the effects of volume-depletion on
the viscoelastic properties of mucus.
Fibrin
and Blood Clotting
Fibrin fibers
are the major structural component of blood clots. Determining the mechanical
properties of these fibers will provide new insights into the wound healing
process and will advance our understanding of heart attacks and strokes.
The nanoManipulator interface is used to locate the modification site,
and a polylinevirtual tip is used to effect the modification.
Gene
Therapy and Viruses
The Resource
has been used to investigate two different virus families, tobacco-mosaic
virus (TMV) and adenovirus. The TMV studies have concluded, but illustrate
the usefulness of manipulation and force measuremnets for viruses on surfaces.
The adenovirus studies are ongoing and investigate shape, stiffness, adhesion,
and rolling behaviors.